I have tried many different things and combinations of things. The one that has best kept me out of the hospital is Zyprexa which is notorious for weight gain. My doctor and I accepted the trade off and I took Zyprexa. On July 9, 2022 i weighed 360 and my A1c was over 8. I had screened out of a bariatric surgery program due to depression. In the last 2 years a drug called Lybalvi has been introduced. It has the same active ingredient as Zyprexa plus samidorphan. The samidorphan is thought to suppress the food cravings that the Zyprexa causes. I enlisted the help of a Registered Dietician who is also a Certified Diabetes educator. I lost approximately 45 pounds over 9 months. The dietician suggested that I see an endocrinologist. The endocrinologist maxed out the dose of Innvokanna and started me on Mounjaro because my A1c was still around 8. The weight really started coming off then. I have lost 82 pounds since July 9, 2022. I still have a long way to go to hit my goal. I’m sure that without the Lybalvi, I wouldn’t be able to function and loose weight.