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DiscussionAfter lumpectomy? What's next?
Breast Cancer | Last Active: Sep 24, 2023 | Replies (18)Comment receiving replies
Replies to "Hi I got my pathology report via the health care portal. Haven't spoken to the MD..."
The weak positive ER and weaker positive PR could mean that estrogen blockers won't be as effective, but they may also still be prescribed since you are not negative. I am not sure who those numbers will affect your Oncotype.
I just googled all the terms, which you can also do- and ask your doctor about this info. I am only posting to help you collect questions and am just a fellow cancer (former) patient.
1) The papilloma and the PASH are both not cancerous. (You can google these.) So that's good news!
Comedo type DCIS is aggressive as you can see from the grade 3 and apparently you want to make sure that it hasn't pushed further out if it is greater than 2.5cm. I assume "occult infiltration" means infiltration not seen on imaging but I don't know if it is seen in pathology : https://radiopaedia.org/articles/comedo-type-ductal-carcinoma-in-situ-4?lang=us
"Comedo-type DCIS completely fills and dilates the ducts and lobules of the terminal duct lobular units (TDLU) with plugs of high grade tumor cells with pleomorphic nuclei and central necrosis ("comedonecrosis").
Infiltrating ductal carcinoma (infiltrative ductal carcinoma with central necrosis) may so closely mimic the pattern of DCIS with central comedonecrosis that on initial morphological analysis these foci of tumors are often labeled as DCIS (high grade, comedo-type).
There is a risk of occult infiltration. A comedo that extends for >2.5 cm has an invasive component in 45% of cases."