Hi! I’m sorry, for the late reply, I just saw this. I started on anastrozole, which was great until two months in, when I developed trigger finger (both thumbs started locking in a bent position). Took a break, it went away, started letrozole, it came back. Then tried tamoxifen, which caused terrible anxiety and depression. Finally went to exemestane, and hooray! No trigger finger (or anxiety)! I do feel ancient and creaky in the mornings, but it’s no big deal. So that’s what works for me, but I know some other women have totally opposite or different reactions to these meds. If one isn’t working for you, don’t hesitate to try another. Take care!