I was laid low the first time Cymbalta 40 mg was prescribed for me…literally laid out on the couch all day due to nausea and dizziness. I only took it one day. But it was a miracle for my Mom, resolving so much of her pain. So I decided to try again and just gut it through. But wisely, my new doctor prescribed a lower dose along with promethazine 25 mg. for nausea. It was successful with only 1 dose of the anti nausea med. I had zero side effects and it helped my sitting pain tremendously. But now I have a new spinal cord stimulator and am trying to get off Cymbalta (and next, Lyrica)and it is very difficult. However, I will keep trying.