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Gabapentin and duloxetine

Chronic Pain | Last Active: Oct 19, 2023 | Replies (14)

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@msr2323

Hello,
I have been on 1800mg of gabapentin daily since my MS dx in 2015. It has been prescribed for the neuropathy (atypical) that I experience in my feet and lower legs. It is not painful, but comes with a very weird sensation of tightness and pressure (I feel like I am wearing shin guards and compression hose).

I am a bit resistant to up my dose of gabapentin and have no idea what I will experience if I titrate down or go off of it. My neurologist prescribed cymbalta to be taken for 3 months to see if it helped decrease any of the neurological symptoms. I took it religiously as prescribed (60 mg/day) and at the end of the 3 months I reported that I felt no relief and that my neuropathy remained the same. I am currently titrating down off of the duloxetine to go off of it.

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Replies to "Hello, I have been on 1800mg of gabapentin daily since my MS dx in 2015. It..."

I was able to come off of 600mg of Gabapentin (300mg 2x daily). My Neurologist told me to stop my morning dose cold turkey, but that increased my pain. My pain doc told me to titrate down much more slowly, and that worked. You definitely need to do it under medical supervision. Good luck.