@jesfactsmon Hi Hank, For what my two cents are worth, there is no reason why your wife cannot do the protocol, and take the Kratom when the pain is severe enough to make her cry, or scream. They really will be ok together. That protocol will not work instantly. It may take some months to feel. Who really knows? I just hate to hear how much pain she is in. Just remember to start low with the pills, perhaps 3 pills, and work up, as needed. Best with lots of water, on an empty stomach, for best results. If she does not get relief, slowly up the pills to find her sweet spot. If you do go to Norm Black, he is a real decent guy. Maybe he would charge you less. Just don't mention I told you so! Ha! Anyway, my best again. I usually have my worst pain at night. Read that neuropathy pain is usually worst at nite, something to do with circadian rhythms. Without medical marijuana or Kratom, I could not get thru the night. Be safe, my friend, Lori