I am an 80 yr old and was diagnosed with high grade urothelial carcinoma in June 2022 with mets in liver and surrounding glands and some bone mets as well, and my Oncologist prescribed Gemcitabine + Cisplatin--two weeks on and one week off each series. While my 1st CT after 4 series (8 doses) showed cancer regression, my side effects of extremely low white blood counts and severe skin irritation and other pretty rough health things caused the Oncologist to discontinue that regimen since in his words "it was doing more harm and risk than good". So, he started my on Keytruda, an immunology drug with nhopes that would take over from there. Unfortunately, after 4 doses of that my CT showed some of the cancer was growing again. As kind of a last resort he started me on PadCev which he says target only white blood cells with cancer and not all white cells. I've been on that regimen since Jan 2023 (24 infusions so far and continuing) and although that seems to having positive results he wants to keep me on it for some time yet since the aggressive nature of my cancer cells seem to want to hide and sometime will come. back. Needless to say the side effects of this regimen have been brutal and i now have a bad case of neuropathy such that i need walking aids and very weak and losing weight, etc.