I am getting to the end of my Folfirinox regimen. 3 more infusions to go. Things that have helped me:

Atropine is a must before iranotecan. I sometimes have a second shot if I continue to experience cramping. After my first session, I lost significant weight due to nausea. They added saline infusions on the day of chemo, on the day the pump is disconnected and two days after the pump disconnect. They also prescribed Olanzapine, which helps with sleep and appetite and was a game changer for me. I’m also trying acupuncture immediately after chemo. The 2-3 days after pump is removed are the hardest, primarily cold sensitivity and fatigue, but otherwise I have been tolerating the treatment well. One more side effect, I had difficulty speaking on the second and third infusion ( called dysarthria). They changed the order that the chemo was infused and that solved the issue. I wish you and your husband well. It is a difficult course of treatment. Ask your medical team for help. Many things can be done to make it more tolerable. Good luck.