@terrydclaar "Hold the Gaba: A Case of Gabapentin-induced Hepatotoxicity
Monitoring Editor: Alexander Muacevic and John R Adler
Christopher D Jackson,corresponding author1 Michael J Clanahan,1 Kiran Joglekar,1 and Sorawit T Decha-Umphai2
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Abstract
A drug-induced liver injury is one of the most common causes of acute liver failure. While acetaminophen is the most common etiology, other offending medications include amoxicillin-clavulanic acid, amiodarone, isoniazid, and fluoroquinolones to name a few. Gabapentin, a gamma-aminobutyric acid (GABA) analogue, has infrequently been reported to cause liver injury; however, the causality in the previous reports is contested. Herein, we report a gabapentin-induced hepatocellular injury in a patient without another identifiable cause for acute liver injury. Discontinuing gabapentin resulted in rapid reversal improvement in hepatocellular injury.

Keywords: gabapentin, hepatotoxicity, drug-induced liver injury

@terrydclaar and @gilbertc1 -- I found this NIH article that talks about the issue but even they say it's not conclusive.

Hold the Gaba: A Case of Gabapentin-induced Hepatotoxicity
-- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093755/

Here's another recent article found on Google Scholar (https://scholar.google.com/).

Drug-Induced Liver Injury in the Setting of Analgesic Use
-- https://www.liver.theclinics.com/article/S1089-3261(19)30072-8/abstract

gabapentin is released through the kidneys and has very little relation to the liver. Gabapentin has shown up in drug related health issues/death when combined with other drugs such as fentanyl. Everything I have read or heard says gabapentin is safe but not without side effects.