I have read the Connect posts to this question posed by @rabbit10 from April 2016 to Sept 2018 (the point where I am now) and I have to say my heart goes out to all you pain sufferers. PN is a horrible affliction. And so many try drugs and are disappointed (except a very few). My wife Linda has had PN since her chemo in 2014. I have been her caregiver since then. It happened just after the 2nd round and at that point she decided to quit chemo. After 4 occurences of breast cancer and surgeries for same over 3 years (2012-2015) she finally arrested it herself by taking Haelan951 (easily fouund online, it is a miracle for cancer of all kinds). She has since had no new outbreaks for over 4 years, to the surprise of her favorite Vanderbilt cancer surgeon.
Anyway, the neuropathy is now her biggest issue. She gets burning feet every day. Periodically she also gets a deep, insanely intense deep itch. She has found significant relief from the itch using a Sonicare electric toothbrush, the vibrations from which get down deep to that itch. But we think that the itch issue may be more from fibromyalgia and perhaps not neuropathy, but who knows and anyway its all nerve-related, right? For the burning she uses a fan blowing on her feet and she must keep the air conditioning at 66 degrees in the summer or she suffers (she loves winter now). She maintains a clean diet and takes a lot of supplements, including a lot of the ones everyone recommends for PN (R Lipoic, Benfo Thiamine, Acetyl L Carnitine, Omega 7 and at least 2 dozen more). She does not excercise much though she knows she should. She just doesn't have any energy most of the time. In doing research online there are a couple things I have found that sounded promising but which we have not been able to try. One is tetradotoxin, which is a substance taken from a pufferfish and is showing promise in relieving PN for up to 10 or 12 weeks at a time. Last I heard it was in phase 3 trials. I communicated with someone working on the study who said it could be years before final FDA approval, but it does sound promising. Search tertrodotoxin for peripheral neuropathy to see links referring to this. Here is one by the company developing it:

Another thing I came across at one point was Calmere Scramble therapy. It is a device, developed in Italy, that seems to arrest or reduce PN pain after a 2 week treatment regimen. The problem with it is that the device costs over $100 thousand dollars. There are a few medical facilities that have the device and offer this treatment around the country (we don't live near any of them) but I found one place in W. Hartford, Ct. that say they will do it for around $5000 but you would also have the cost of staying there for 2-3 weeks. And if it lasts 10-12 weeks it means you would need to return for further treatments. But apparently some people have sworn it has helped them. Here is a link:

Another thing we got for Linda is an Infrared light, well two different ones, actually. She used them on her feet for a couple months but stopped after she upped her sessions from 15 minutes to 20 minutes and felt she was getting burned. So this has not turned out to be too promising as yet.

Linda would like to try medical marijauna but it is illegal in Tennessee right now. Hopefully that will change soon. She has tried cbd oil and has also tried kratom, but has not been helped by either.

After reading through the first 68 pages of this website, one thing that sounds promising to us is Bob Diamond's protocol on Facebook which @johnbishop has mentioned. My wife wants to try this out soon. The only thing that worries Linda is the high (1200mg/day) dose of r-lipoic in the protocol. She has trouble tolerating the 240mg Life Extension pill she takes now, as it makes her nauseous. But she is going to give it a try anyway. She is so ready (as am I) for her to be able to have her life back. She is unable to travel to see my 98 year old mother whom she loves because of this ridiculous problem. She wants to be able to get out and do things again. She knows she is better off than many who suffer from PN but it's not any fun for anyone. If I find out anything new in my own research of PN I will let you all know about it. Best wishes to everyone.

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