@rramsey @johnbishop...I am doing a little research on this issue of compression socks as people were recommending these compression socks to me as a solution. I am convinced that these socks are not for SFN as SFN does not cause swelling of the feet or legs normally due to do to a myriad of things including inactivity, poor blood circulation etc. In doing this research I did come across a rare condition called Vasculitic Neuropathy. A paper published in 2005 called "Skin Denervation in Vasculitic Neuropathy" provided some insight. I am beginning to think this maybe the cause of my SFN. Since my feet symptoms are so unusual, I am beginning to think that this is an autoimmune problem affecting the small blood vessels in my skin. Since I am reading the book co-authored by Deepak Chopra called "Super Genes" (about Epigenitics), this may be due to an acquired genetic mutation or other environmental cause. The term "aaSFN", now in common use", suggests an apparently autoimmune SFN which might be treatable with iVIG or Plasmapheresis. Perhaps this is why Dr. Argoff suggested these treatments and why studies are being done with those seemingly idiopathic for SFN. Circulation problems can cause SFN in diabetics, for example. However, the vasculitis (inflammation) in this case affects the smaller capillaries in the skin that work with the small fiber nerves to provide normal blood circulation. Inflammation of these vessels is a lot different than inflammation/blockage of blood in the above described circulatory system (veins and arteries). John, would you know more about this type of vascular neuropathy? I am getting bogged down in terms such as methylation and other causes of mutations and causes of possible yet unknown autoimmune diseases...Even if it goes nowhere, it is an interesting topic (and book). Pam