Hi Registrar. I am not sure what you mean by a "pleural based nodule". I have multifocal adenocarcinoma (lung cancer). I have multiple nodules at various "life stages" (size and solid, part solid). There are several of us on Connect with this type of lung cancer. They start out as "ground glass" opacity and eventually if they become solid, they are treated. Treatment options depend on where they are located in the lung and if they have gone to the lymph nodes. Since Dec 2021 I have had two VAT wedge resections (surgery) and one round of SBRT (radiation). Total of 3 nodules treated. Fortunately, my lymph nodes have been negative, so I have not needed any chemotherapy.
I had a case of pleurisy-fluid which fortunately resolved itself. It shrank on its' own, cause unknown. Had it not resolved itself, there would have been concern that cells from the previous surgery had fallen there.
I am under close observation now because I also had STAS (spread through air space) for one nodule, it shed cells in the lung.
Look for a Pulmonologist experienced with lung cancer in a center able to provide all types of treatment options including video assisted thoracic surgery.
How long have they been tracking your nodules? Has there been any growth? I would tell them if I were not comfortable with too long a period.

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