I am trying LDN. I started at 1.5 and then 3.0 for a few months with no noticeable improvement. I do have to take it in the morning to avoid insomnia. I have just recently started 4.5 and am seriously reconsidering it. I find myself taking deep breaths (anxious) and my sleep is horrible, not to mention daily headaches. I know it can take time but not sure it’s worth the trial period. I also take the gummy Coq10, no noticeable difference in my LHC symptoms.