I've been on various treatments for 10 years with this disease. I can say that fatigue is probably the biggest factor. I take 5 hour energy shots sometimes. I have been on Percocet for pain all these years as needed. I have the worst type of aggressive prostate cancer with metastatic bone cancer. I have exhausted all treatments and currently waiting for the next clinical trial. The only other thing I can tell you is that a strong mind helps, and that's me.