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How accurate are the PSA Tests?

Prostate Cancer | Last Active: Sep 27, 2023 | Replies (35)

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@jc76

I have not had my first PSA test after radiation (Proton) treatments. It was 3.75 prior to treatments. I am on of those individuals showing you can have prostrate cancer and still have a normal level PSA.

My Oncologist/Radiologist at UFPTI in my post treatment information stated the same thing about testing. That it should be at the same lab each time due to difference in labs which will affect the numbers. I am having my PSA test done at Mayo and my primary care doctor stated the same, to make sure I did each at same lab.

I am a little confused with some postings. What is considered a good PSA number after treatments. Is the first PSA after treatment not a good predictor of success or failure? Is the norm that your prostrate is still inflamed and irritated for the first PSA test which I assume is 3 months at most providers like mine is scheduled for.

I did read about biking. My primary care doctor and I were well informed about this as we thought my rise in PSA numbers was caused by bike riding as I was riding 25 miles couple of times a week. Then we did a plan not to ride 48 hours prior and then 72 hours. It went down a little first time but then rose again second time. It is then my primary care doctor referred me to Urologist.

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Replies to "I have not had my first PSA test after radiation (Proton) treatments. It was 3.75 prior..."

Here is what I've found for you about PSA readings. The Hopkins site says "After treatment with radiation, PSA levels rarely drops completely to zero. However, the PSA should level out at a low number, which is called the nadir. When PSA rises 2 points from its lowest value, the cancer is considered recurrent." If one has had surgery it says "After surgery, PSA levels should drop to zero. When PSA levels rise above 0.2 ng/mL, the cancer is considered recurrent." Scroll down the page to the section labeled Long-Term Prognosis and read from there on down. (The source for above info is https://www.hopkinsmedicine.org/health/conditions-and-diseases/prostate-cancer/prostate-cancer-prognosis)
The next site says "The pattern of the drop in PSA after radiation therapy is also different from after surgery. PSA levels after radiation tend to drop slowly, and might not reach their lowest level until 2 years or more after treatment." Next, read the section labeled After Radiation Therapy (source is https://www.cancer.org/cancer/types/prostate-cancer/treating/psa-levels-after-treatment.html)