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@britelite

To radapanich - a couple of months into my long covid journey, my PCP prescribed Medrol Pak for chest congestion & SOB. It’s a 5 day course of methyprednisolone where you take 6 tablets the first day and decrease it by 1 tablet every day. On the 3rd day, my blood pressure shot up to 190/100. By the time I got to the ER, it was 210/110. Scared me to death - afraid I was going to stroke out. I was trending toward hypertension anyway so now I’m on Amlodipine which controls my BP nicely. The ER doc said prednisone can elevate the BP but usually not to that extreme. Anyway, that was just my reaction to it and I wish I could take it again to help with my inflammation symptoms. So just monitor yourself carefully and good luck. Hope you feel better on it.

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Replies to "To radapanich - a couple of months into my long covid journey, my PCP prescribed Medrol..."

Medrol Pal at 6 tabs per day is 24 mg per day. Assuming that the Medrol was a 4 mg tablet, which is standard for Medrol Pak, that would be 5 x times higher dose than 5 mg . I am so sorry that you went through the frightening experience. I am glad that it resolved. Idiosyncratic drug reactions do occur and our bodies respond to drugs differently. Hopefully you will find a medication that works well for you. The post acute Covid specialist / immunologist advised using aspirin 84 mg, Lipitor (statin) 10 mg, an antiviral Paxlovid, prednisone 5 mg. The first two drugs are for control of possible microclots, one of the potential mechanisms of long Covid. She said that the antivirals do have side effects. I take Lipitor and aspirin anyway because I had a stroke previously, and low dose naltrexone 4.5 mg (a ordered by my PCP from Mayo pharmacy), which helped with brain fog. Best of luck with finding an effective treatment. Because primary care physicians may not be aware of all the ongoing research , be your own advocate, guide them (gently) toward studies and mention Mayo Clinic studies, which haven’t been published yet in medical literature.

I use the Medrol dose pak too. But I cut it in half and take half the descending dose. Works like a charm for me. Prednisone is sl different from methylprednisolone (Medrol Dosepack). They result in different side effects, if any are going to occur. I can't tolerate Prednisone but can tolerate Decadron and methylprednisolone well at low doses. And I get the same desired effect at half doses. One size does not fit all pharmacologically.
Sorry you didn't tolerate methylprednisolone. If you ever need it again, you might mention to your prescriber that you'd like to try a half dose. They should be agreeable based on your experience.