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Does adrenal insufficiency with unregulated inflammation cause flares?

Polymyalgia Rheumatica (PMR) | Last Active: Aug 30, 2023 | Replies (17)
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@christopherc

Thanks so much for this thorough and thoughtful response. It’s very helpful to me and I’m sure to many other members of this group. I hope the Actemra continues to work for you and you are truly in remission and stay there.

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DadCue | @dadcue | Aug 30, 2023

The following link talks about a research study with Actemra (tocilizumab) for the treatment of PMR. So far, Actemra still isn't FDA approved for PMR. However, Actemra is FDA approved for the treatment of GCA.

https://www.medpagetoday.com/rheumatology/generalrheumatology/100815

This link might work better:

https://www.ajmc.com/view/tocilizumab-leads-to-improvement-in-patients-with-active-polymyalgia-rheumatica-despite-prednisone-therapy

I don't have GCA so my rheumatogist submitted an authorization request and got Actemra approved for me. The approval authorized my rheumatologist to treat PMR with Actemra under the same guidelines used for GCA.

There is now another biologic that is approved for PMR. This biologic is called Kevzara (sarilumab).

Kevzara and Actemra are 2 different biologics but are in the same classification. The mechanism of action is basically the same.

https://www.ajmc.com/view/sarilumab-indication-expanded-to-include-polymyalgia-rheumatica
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