@mommacandy, I am on a slightly different version of this being that I get the liposomal irinotecan instead of the irinotecan but all the other drugs are the same and I have been through 10 rounds so far. Everyone’s experience can be different so getting through the first rounds, you may have to just see how it goes and let your doctor know of any effects as they can prescribe things to help. In general I don’t feel very well for a few days and just generally lay on the couch for most of the day although I do go for a walk every morning but have had no issue with diarrhea or vomiting. I do take Olanzapine at bed time for the first 5 days of chemo and suspect it helps a lot and it does put me out at night so I sleep pretty heavily for those nights. I have had no issue with the chemo pump as it comes with a fairly long tube and I don’t move around a lot at night so just lay it on the nightstand beside me. I did forget about it one time getting up to go to the bathroom and it hit the deck but fortunately kept on ticking. For chemo days I pack my lunch and snacks and entertainment items and I drink a lot of water. I’ve been advised that the water will help flush the chemicals through so I’m just constantly drinking it. The nurses in the infusion room are a wealth of knowledge so I recommend asking them any questions you may have. I wear gloves on my morning walks for several days to deal with the cold and I don’t eat cold things…yep, gave up my favorite dessert, ice cream. To be honest my tastes have changed and things I used to love to eat don’t sound as appealing. I hope everything goes well for you!!