I am 2/3rd’s of the way done with my mFolfirinox regimen. The first one was the toughest for me. My oncologist added saline fluids on the day of chemo, on the day of pump removal and 2 days after pump removal. She also put me on Olanzapine which has been a lifesaver, helping with nausea, sleep and appetite. My neuropathy is mild as is my cold sensitivities. Make sure you ask your team for things (like saline fluids and Olanzapine) that can help with the side effects. Good luck.