I would like some help deciding how I should discuss future treatments for my high grade urothelial metastatic carcinoma which was diagnosed in June 2022. I am 80 yrs old with no prior cancer and this has been quite a journey. The Oncologist started me on Cisplaten/Gemcitabine but after 7 infusions with a CAT scan showing positive results he discontinued that therapy due to a side effect of severe low white blood cell counts. He then started me on Keytruda but after 4 infusions my next CAT scan showed negative results and some regrowth of the liver lesions and bone cancer. He has had me on a targeted chemotherapy called PadSev since January and successive CAT scans show Kidney issues and liver lesions are gone and bone cancer reducing and healing. Needless to say that severe chemotherapy for the past nine months has resulted in neuropathy in my feet and hands such that I am needing walking assistance and other nerve and skin issues.

The Oncologist wants to continue my chemo regimen of two infusions every three weeks for the indefinite future--as long as I can tolerate it--since that is the only approach that will keep my cancer from returning and becoming more aggressive. I'm not sure I can continue to have my neuropathy worsen, and wonder what other options the Oncologist has that I could perhaps discuss with him.

Does anyone have any thoughts? Thanks!!.