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@dadcue

Thanks for the response. I'm interested in anyone's opinion to this question.

Two of the links seem to support the idea that adrenal insufficiency at least contributes to our need for long term prednisone. The second link says the following:

"Most of the glucocorticoid-insufficient patients could discontinue prednisolone with appropriate treatment for adrenal insufficiency."

I wonder what "appropriate treatment for adrenal insufficiency" they are referring to. The only treatment I know about is supplemental doses of corticosteroids like prednisone. Taking more prednisone won't let anyone discontinue corticosteroids any sooner. In some cases, supplemental corticosteroids are needed for the rest of their lives if their adrenals don't start producing cortisol in adequate amounts.

The third link says:
"Assessing the adrenal function in patients with PMR will contribute to establishing a more appropriate glucocorticoid reduction strategy."

My endocrinologist would not assess my adrenal function until I could stay on 3 mg for an extended period of time. Most people seem to experience flares at 7 mg of prednisone. I have read that 7 mg of prednisone is the physiological amount of cortisol that a person needs on a daily basis.

"In normal adults, the adrenal glands produce approximately 5 to 10 mg/m2/day (body surface area per day) of cortisol, which is equivalent to 5 to 7 mg of oral prednisone or 20 to 30 mg of hydrocortisone."

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Replies to "Thanks for the response. I'm interested in anyone's opinion to this question. Two of the links..."

@dadcue - Have you seen these references?

--- Patient education: Adrenal insufficiency (Beyond the Basics): https://www.uptodate.com/contents/adrenal-insufficiency-beyond-the-basics
--- Primary Adrenal Insufficiency Guideline Resources: https://www.endocrine.org/clinical-practice-guidelines/primary-adrenal-insufficiency

Hi dadcue. Your original question and subsequent comments are great! I have had the same question and have been unable to find sufficient answers.

I don’t know if you have this option where you reside, but here in Seattle we are able to order our own lab tests from the same lab used by my physician. So I am able to check on things like am cortisol that my physician might have trouble justifying to insurance companies/Medicare. I am at 6mg doing a slow 5 week taper down to 5. I haven’t tested my cortisol yet, but am about to.