Hi, @johnbishop thanks for all of your input

Wow! There's been a lot of activity and information-sharing recently. I thought I'd add my two cents.

I'm taking 1200mg of gabapentin daily. I also take a 500mg magnesium tablet in the evening. Even with the medication and supplement, I've had severe muscle spasms in the evening and at night. I've had idiopathic peripheral polyneuropathy for 23 years, but 3 years ago the muscle twitches and creepy-crawly sensations began in my feet and legs in the evening. After having tried just about everything else (including the soap under the sheets), my neurologist was about to prescribe quinine for me, but after researching the side effects of the medication, I decided against it--at least for now. While doing my research, I found a Japanese study using a vitamin B therapy that was fairly successful, and my neurologist gave me his blessing to try the same therapy. I've been taking B1, B6, B12 and riboflavin in about 30mg doses 3 times a day, along with the gabapentin. And also I take 1000mg of B12 every evening. What I'm taking is the OTC Nature Made B-100 vitamins. I also sip water laced with tonic water throughout the evening. I've been on this regimen for over a week. I had no muscle spasms last week, just slight twitching in my feet and legs in the evening. I can live with that and the neuropathy which is primarily weird, arbitrary sensations, but the awful spasticity and cramps that keep me up at night sobbing in pain truly are torture.

If anyone else has tried the Vitamin B therapy, please post a reply with your thoughts. Thanks, everyone.

I am taking alpha lipoic acid (ALA) and B vitamins for neuropathy. I have been told to watch the form the B vitamins are in. Bs are not well absorbed by the body, and the form they are in helps with absorption. B1 should be benfotiamine, not tiamine HCI, B6 should be Pyridoxal-5-Phosphate (P-5-P) not pyridoxine HCl, and B12 should be methylcobalamin not cyancobalamin. It doesn't matter how much of these we take, if the body is not absorbing them, we just flush them away! Also, you might want to check the tonic water; I do not think it contains quinine anymore. I also use magnesium, but I get the liquid form called Re-Mag on line. It has helped me tremendously with the leg cramps and also has made my nails stronger -- finally a side effect that is positive! I do know what you mean about the leg cramps as I've been there often. I tried the soap too, but to no avail. Hope this helps a bit,

Hi @magg, there has been a lot of sharing which is great! I would just caution folks to always check with their doctor or pharmacist if you are taking other medications to make sure there are no concerns or conflicts with your current medications.

I take B12 and Biotin as part of my supplements. I take the liquid form of B12 which has more bio-availability. I take 2ml (5,000 mcgs) of the B12 in the morning and 2 ml at night. I take 2 Biotin 10,000 mcg capsules at noon each day. I have to take it at least 2 hours before or after I take another supplement (sodium stabilized R Alpha Lipoic Acid 1200 mg daily) that's part of my daily supplements regimen. I also take Magnesium 200 mg tablets - 2 in the morning and 2 in the evening for 800 mg daily. I had a discussion with my doctor who ran the list of supplements I am taking by the Mayo pharmacist.

I wished more research was going into the fix the problem - damaged nerves rather than on block the pain and make it go away symptom. If you can repair the nerves or start repairing them, the pain will go away or lessen as the nerves come back to life...unless they are severed, crushed or damaged beyond repair. Layman patient with zero medical knowledge or background is speaking here of course.

I really do hope each and every one of you find something that helps. I don't have the pain that a lot of you do but I do have the numbness and tingling. I have also had the old man's walk since I was in my 50's which was reported to me by my better half.

John

Thanks @amkaloha and @johnbishop. I was taking alpha lipoic acid for several months, but didn't notice a difference in my symptoms. What did help at the time was the B12 I started taking. Within a week after starting the B12, the shooting, electric-like pains and tingling diminished significantly. I'll try the B vitamins you suggest if I'm not taking the right ones. I'll also try the liquid magnesium. I'm really open to anything at this point. Tonic water does indeed contain quinine; it says so on the label. I like the taste also. You just can't buy quinine tablets over the counter anymore; the FDA discontinued them in the 1990s because of the side effects. But I understand that it was very helpful to people with leg cramps. A question for either of you: Where do you get your vitamin supplements? I've been ordering mine from Puritan's Pride for several years.

That's interesting about the quinine. I knew the FDA did take it away in some form. Interesting that they left it in the tonic water! As far as getting supplements, Vitacost.com has a wonderful site and they are cheaper than other sites. I get my magnesium from Dr Carolyn Dean's site. You can google Re-Mag. She has a lot of information on her products. My husband takes this form of magnesium also for his heart arythmeia. She has info on that too. There are many forms of magnesium, some act like a laxative, others calm you. I think it's important to know or you won't get the results you are seeking. Good luck to you.

Thank you! I'll check out Dr. Dean's website.

I order my supplements through Amazon.com and get the 2 day free shipping with the Prime membership. I buy the Seeking Health brand of B12 - Optimal Lipsomal Active B12 with L-5-MTHF. I currently use the Dr Best's High Absorption Magnesium 200 mg tablets but have been thinking of switching to capsule form that is supposed to have a higher absorption. I will have to check out the Re-Mag.

Thanks!
John