Here, I just want to help my brother-in-law. My brother-in-law has been diagnosed with High-grade sarcoma or leiomyosarcoma.

Here are the details:
Diagnosis: The biopsy from a retroperitoneal mass is identified as High-grade sarcoma or leiomyosarcoma.

Supporting Information:
History: The patient presented with a large mass in the right retroperitoneal area. This mass has spread extensively to the liver and lungs. There's a clinical suspicion that this mass is a sarcoma. The CT scan indicates the features of a retroperitoneal sarcoma that has infiltrated nearby organs including the right kidney, right ureter, IVC, and abdominal aorta. Additionally, the CT scan shows that the cancer has metastasized extensively to the liver and lungs.

Nature of the Specimen: The biopsy of the retroperitoneal mass was obtained with the help of ultrasound guidance.

Gross Features: The biopsy includes multiple strips of tissue that range in size from 3mm to 15mm. These strips were all placed in one block.

Microscopic Details: The biopsy displays malignant cells that are spindle-shaped. These cells have a variety of features such as nuclear changes, the arrangement of cells, the presence of tumor necrosis, and more. The cells are particularly notable for their aggressive appearance and activity.

Immunohistochemistry: This is a test that uses antibodies to determine the type of cells present in the biopsy. In this report, the malignant cells tested positive for certain markers like smooth muscle actin, desmin, and caldesmon. Some cells were weakly positive for CD34. The malignant cells did not test positive for MDM2, S100, stat-6, and myogenin.

Does anyone have a similar story? If so, how are you doing now, and could you share your story and treatment methods? Thank you.