I had the HDR done at Mayo in Rochester. Side affects consisted of fatigue for 3-4 days after each of the treatments. My radiation oncologist had me start flomax the night before the initial treatment and I was on this for 5 weeks. Did have some mild urinary symptoms during this time but nothing severe. I did develop ED which occasionally happens but this is improving. I was able to return to my regular exercise routine within a week of each procdure and 2 months after treatment I went rafting and hiking in the Gates of the Artic NP for 2 weeks.