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Want to connect with people dealing with hypnic headaches
Headache & Migraine | Last Active: Dec 9, 2025 | Replies (57)Comment receiving replies
Hello did you find that the indomethacin kept its efficiency for a long time compare to other meds that would loose its efficiency over weeks or months? Its important to take the 'slow release' tablets? I will discuss it with my neuro. Do you also need to take the melatonin now? I've read various comments here and indomethacin seems to be the 'go to' for hypnic headaches after caffeine... For a while caffeine alone was doing the job for me but the past 4 years it has lot some effect and is not enough. The only thing with the indomethacin its a nsaid wich could be bad for the stomach etc.. May i ask how long youve been taking it ? Thank you
Replies to "Hello did you find that the indomethacin kept its efficiency for a long time compare to..."
@benchi300 I’m still taking indomethacin nightly. Along with Melatonin. I do take a preventative prescription medication also, due to the G.I. risk of indomethacin. It’s called Protonix (pantoprazole)). So far it has prevented gastric complications.
@benchi300 how are your headaches now? I hope you got some professional help. I was just wanting to update my reply since its about 1-2 years later. Indomethacin (us melatonin and no more nocturnal coffee) does still prevent the "hypnic" type headache about 92% of the time. I was encouraged to slowly dose of indomethacin from 75mg gradually to 25mg per night at the urging of my MD from Mayo and from Kaiser. If I take no indomethacin (which I do twice yearly to see if I still need it), I get a very sickly nocturnal headache (and awaken multiple times through the night) and the last awakening my headache is pounding and relentless. I have severe nausea and the pressure in my ears and behind my eyes is severe. I keep injectable Toradol to use for those episodes. After those episodes, I always have a low grade persistent headache and moderate nausea for about 5-6 days. I'm also more prone to migraine breakthrough after those "trial" withdrawal of Indomethacin.
As for the coffee at night, I no longer need to drink it. In the past, I always drank either medium or dark brew (various brands). I am now taking Ajovy for migraine prevention and it works about 26/30 days monthly. I took Emgality for several years for the nocturnal headaches (not migraines) and it seemed to be a bit more effective than Ajovy for me, but I had to pay for it as there were no CGRPs on the formulary at Kaiser when I first began preventative treatment with a CGRP. Ajovy is now on formulary and my copay is less than half the price I paid for Emgality.
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