@lucychristine46 what is PMR. I seem to react to everything as well. I have autoimmune disorders and kidney disease, not sure if those account for it but my sensitivities date back to treatment for Lyme.

I tried to get on various osteoporosis meds for years and even saw an immunologist to help me. As I have written before on this site, I finally managed Tymlos because the dose is adjustable, and I could start low and move up cautiously. I have now been on it almost two years with wonderful results.

There is discussion on this elsewhere but sequencing is important and it would probably be better (McCormick, Leder MD, my doc) to start with a bone builder (Tymlos, Forteo, Evenity) before an anti-resorptive (bisphosphonates, Prolia) to have the most effective treatment.

Getting off Prolia is tricky. The standard thing is to do Reclast 6 months after your last Prolia but for some that is too early (in which case Reclast won't work) and for some it is too late (in which case bone density drops and fracture risk rises). McCormick discusses this in his book "Great Bones" as others have said. My doc doesn't use Prolia for this reason but McCormick uses the CTX and P1NP blood tests. I get those through my PCP and see McCormick as well as my endocrinologist.