I've been taking various PPI meds for well over 20 years, so much more convenient than baking soda and longer-lasting than Tums. Most of that time I was on half a dozen other meds as well, all of which I gave up 3-4 years ago. Two years ago a doctor told me my omeprazole was counteracting my calcium, which I took for osteoporosis, so I asked the pharmacist for clarity. She told me to stop the PPI, that it would get worse before it got better, and to take calcium citrate for my bones. The simmering cauldron that was my stomach turned into an active volcano. Like most people, I am part stoic and part wimp, and my stomach has always been where I'll do anything to stop the pain as long as it's fast. I stopped the calcium citrate, instituted an extremely bland diet, and still suffered many weeks before finally resuming omeprazole, which now doesn't work nearly as well as it used to and I'm stuck on bland. I spread out my calcium over the day hoping to get enough when the antacid is waning so my bones don't lose excessive density, but that may be wishful thinking. Comments?

Oh, dear, completely forgot to mention that neuropathy did turn up five years ago, but till now I hadn't heard of the PPI connection. Plus, I'm not convinced it really is neuropathy ... so there's that. All comments welcome, of course.