Thank you Sue for the information on divided usage of LDN. I am up to the preferred dose of 4.5 mg. but I know some people require more and some less. Does your husband still have RA flares and does he feel they are milder because of LDN? Im not sure what the expectations are but I hope the LDN combined with my MAC treatment will relieve the debilitating fatigue. Glad your husband is doing better and regained some of his zest for life.