Have you tried incorporating SAMe. It’s a natural serotonin uplift and as far as I know does not interfere with Rx remedies!
My daughter has chronic clinical depression and at this point after multiple meds she went off most everything but we are all facing the penalty of her decision. She won’t take anything except doctor prescribed.
You can get SAMe over the counter but make sure you get the right brand. Cosco has it. Nature’s…..now you’ve got me. I have Lyme disease for over 35 yrs and have tried it. It works. But in severe cases it going to take higher doses. You must start off with the lowest dose and be persistent in working up. If you need help with all this, a good friend or holistic practitioner in partnership is your best bet.