At 83 y/o I still use small dose estrogen. My family history is high in strokes and heart attacks. I had to be referred to a gynecologist who would prescribe it b/c after my move to a new state, my new primary care doctor would not write my prescription. I take it b/c of what I consider its miraculous skin effects. Those effects improve my mood and thus my quality of life. I have 2 daughters who have reached midlife and they refuse to take it. It is a personal decision each woman must make on her own.