Hi Sequoia, I'm so thankful it's not just me. I am sorry to hear you cannot take Anastrozole or anything else. I didn't take it as long as you. I was only taking it for about 6 months. I started feeling better almost immediately. Maybe part of that was psychology. I felt like I was ingesting poison. I also did such a lot of online research. At one point, my onco's nurse gasped on the phone because I told her I had a couple of pages of questions. Well, of course he handled my questions beautifully. If all providers were as nice as he is, I wouldn't have nearly the problem with going to the doctor. I have one real-life friend who had a small lump like mine only hers was right next to her nipple so they did a mastectomy. She had reconstructive surgery about a year later. She took tamoxifen for 5 years with no problem other than going through menopause. She is about 10 years younger than I am. And for her this all happened in 2007. I wish I could have taken something with no bad side effects, because there's always that worry. I am trying to find a surgeon now who will do a total hysterectomy so I don't have to worry about those organs at least. Good luck and blessings to you also.