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@sueinmn

I don't think they get into the system that fast - I believe that taken daily over time they have a lasting impact on the mucus. For example, if I stop Mucinex, I don't notice the thickening mucus for a day or two. With NAC, I ran out last winter, and noticed a difference after 4 days.
Sue

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Replies to "I don't think they get into the system that fast - I believe that taken daily..."

That seems logical, according to drugs.com, some effects of guaifenesin should be noticed within 30 minutes of taking it orally; however, up to two days of regular dosing may be needed before the full effects are seen. Presuming same for NAC.
https://www.drugs.com/tips/guaifenesin-patient-tips
Thanks so much @sueinmn for the tip to take NAC/mucinex together as it has helped me clear and seems to keep me clearer than only using NAC.