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ARINA-1 Clinical Trial with nebulized solution-NO ANTIBIOTICS
MAC & Bronchiectasis | Last Active: May 20 8:03pm | Replies (60)Comment receiving replies
Linda, In my last visit I brought Arina-1 up to my Pulmo. It was clear he had not heard of it. I just messaged him about the study you posted. Dr Douglas Hornick in the specialty pulmonary department at the University of Iowa Hospitals and Clinics. He specializes in Cystic Fibrosis and Bronchiectasis, difficult pulmonary infections etc. I would love for U of IA to be included if they are receptive. Is there any way to facilitate that? also I would very much like to know the difference between nebulizing Arina-1 and glutathione mixed with saline. I try to do that every other day. I would love to get involved but nothing is close to me. I do produce abundant mucus! And have chronic Pseudomonas. Also wondered if any of the Drs discussed the use of CFTR modulators for NCFBE? I have been reading there is some thought of that? It has been such a huge game changer for the CF people. THANK YOU for all you are doing!
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I’d love to see Mayo Clinic participate!
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Hi Irene,
The researchers only need 25 more participants and are not enrolling new test sites.
I'm sorry to hear you produce an abundant amount of sputum. I'm sure it impacts your quality of life and I am hoping ARINA-1 comes to market and makes your life easier. From attending the World Bronchiectasis Conference, I also know there are also other trials addressing pseudomonas.
I knew someone would ask about nebulizing glutathione and how it compares to ARINA-1. I discussed this topic with Renovion and this is what they said, "ARINA-1 is a pH-balanced, sterile formulation that is manufactured under strict manufacturing guidelines that ensures the product is exactly as it should be and is of the highest quality and is sterile. Supplements you purchase online are not regulated and do not necessarily follow strict manufacturing and testing guidelines, so the contents and sterility of the product may be questionable to unsafe to inhale.
Further, the inclusion of ascorbic acid into the formulation is critical because glutathione and ascorbic acid work together in the glutathione-ascorbic acid cycle. Without ascorbic acid, glutathione is unable to perform all the innate immune functions that are required to decrease mucus viscosity, move mucus out of the airway, and decrease inflammation. Ascorbic acid and glutathione work in a complementary fashion and both are critical to restoring innate immune defenses, such as mucociliary clearance and downregulating inflammatory processes. One or the other is inadequate.
Supplementing high doses of ascorbic acid orally can be dangerous and lead to side effects such as severe gastrointestinal distress and renal dysfunction and failure. Further, it will not get to the lungs, where the ascorbic acid is needed most.
Inhaling products that are not made under strict Good Manufacturing Practices (GMP), including follow-up testing to ensure the product is not degrading and maintains sterility, can be very dangerous to the health of the patient."
Please let me know if this is clear. Thank you for your interest in participating in a clinical trial to move BE/NTM research forward! Warm regards, Linda