I was diagnosed with PMR in May. Started on 12 mgs of Medrol. Started Actemra in July. Have my second infusion next week. Still taking Medrol. The pain is significantly better but I don't know if it is from the Medrol or the Actemra. I had no side effects from the infusion. Dr. said it starts to work around month 3 and they would start tapering me off of the Medrol.