Ours were from top GI cancer centers with oncologists with lots of pancreatic cancer experience. However, thinking out of the box means recognizing that this cancer originated from cellular replication mutations common to other cancers. Standard of care must incorporate this information rather than simply identifying the tumor and treating this gross manifestation of the cancer. In my husband’s case, the errors in his BRAF mutation are also found in melanomas and gliomas. For many others, the same mutations are more commonly manifest in colon or breast cancers. Therefore we need to target the initial breaks and mismatch repairs and attack those as well as cutting out or killing the visible tumor.