I was on Prednisone 10 mg for over a year and neuropathy in my legs went almost away about 90% of the time, but I started getting side effects from it, gained 30 pounds, high blood sugar, high cholesterol so the Certified Registered Nurse Practitioner, decided we will take you off it. So he lowered me to 5 mg for a month then now I am at 4mg a month and now my Neuropathy in my legs returned to what it was before I started taking 10 mg of Prednisone. It is dang if you do dang if you don't. Keep the 10 mg and have almost no neuropathy pain and have all the prednisone side effects, or no prednisone side effects and have neuropathy pain 24/7. Oh just realized this is an old thread.