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The lowest effective dose, how is it defined?

Polymyalgia Rheumatica (PMR) | Last Active: Oct 28, 2023 | Replies (56)
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@magluchi

I’m 8 years on prednisone now and looking at alternatives. Would you mind sharing what the other medication is that you switched to? And, when you started titrating off Prednisone what was your daily dose?

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Replies to "I’m 8 years on prednisone now and looking at alternatives. Would you mind sharing what the..."
DadCue | @dadcue | Aug 12, 2023

A biologic called Actemra (tocilizumab) was prescribed to me for PMR. However it isn't FDA approved for PMR. I was treated with prednisone for 12 years. The lowest dose of prednisone I could maintain was 10 mg before Actemra was tried.

A similar biologic called Kevzara (sarilumab) was recently FDA approved for PMR.
https://www.pharmacytimes.com/view/fda-approves-sarilumab-for-adults-with-polymyalgia-rheumatica

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