@brighterdays
I started on Letrozole 2 weeks after I finished my final, 37th, radiation treatment. I remember my oncologist saying let's give your body a break before we start the meds then surprised when just two weeks after radiation the break was over.

At the end of my radiation treatment I was so fatigued I could hardly walk across the room and my skin was pretty thrashed - open wounds 8" x 12" area at that point using silvadene burn cream. Although I had improved in the two weeks before I started Letrozole, I remember my skin was not healed yet. I can't remember exactly how I felt after the two week break as that was 2/2021. Then I started Kisqali one week after the Letrozole. My oncologist gave me both meds at once, but I separated the meds by a week so I would know if one med caused any serious reactions. I've been taking both meds for 2.5 years now and plan to continue as long as they keeping working. Best of luck with the meds.