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The lowest effective dose, how is it defined?

Polymyalgia Rheumatica (PMR) | Last Active: Oct 28, 2023 | Replies (56)
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@johnbishop

Hi @megz, I can post the link for you but the problem is that it is old information (2011) and I think it's changed some --- The correct prednisone starting dose in polymyalgia rheumatica is related to body weight but not to disease severity: https://pubmed.ncbi.nlm.nih.gov/21569559/.

Here is some updated information from 2023 and 2022:
--- Treat-to-target recommendations in giant cell arteritis and polymyalgia rheumatica: https://ard.bmj.com/content/early/2023/02/23/ard-2022-223429
--- Polymyalgia rheumatica: An updated review: https://www.ccjm.org/content/87/9/549

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Replies to "Hi @megz, I can post the link for you but the problem is that it is..."
megz | @megz | Aug 10, 2023

I think the weight/dose relationship study of 2011 is still valid in that it points out that 78% of people around 67kg responded to a start dose of 12.5mg but non-responders generally weighed more. Just interesting to me that weight makes a difference to the effective start dose.

The updated information link says the start dose should be 12.5mg to 25mg depending on the risks of individual patients. Since I had a heart attack a few years back and am not a skinny person, I'm pleased to have been started on 15mg, and it did work to get rid of pain within a week. Discussion with my pharmacist indicated that 15mg is a usual start dose (Australia) in any case.

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