← Return to The lowest effective dose, how is it defined?

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@megz

The start dose for PMR varies from country to country with the US most often starting at 20mg and Australia, where I am, starts at 15mg. An Italian study (2011) found that 78% of people started on 12.5mg responded well, but effectiveness depended on the weight of the person with heavier people needing to start on 15mg.
I can't yet post links. Title is "The correct prednisone starting dose in polymyalgia rheumatica is related to body weight but not to disease severity".

I think I would have struggled more with the reductions above 10mg if started on a higher dose. Also, I ignored the directive to stay on 15mg for a month, knowing that in the first 2-3wks of prednisolone treatment the dose can be reduced more quickly without adverse effects. So I dropped as much as I could in those first 2-3wks (15mg down to 11.5mg) to get a head start on reductions.

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Replies to "The start dose for PMR varies from country to country with the US most often starting..."

Hi @megz, I can post the link for you but the problem is that it is old information (2011) and I think it's changed some --- The correct prednisone starting dose in polymyalgia rheumatica is related to body weight but not to disease severity: https://pubmed.ncbi.nlm.nih.gov/21569559/.

Here is some updated information from 2023 and 2022:
--- Treat-to-target recommendations in giant cell arteritis and polymyalgia rheumatica: https://ard.bmj.com/content/early/2023/02/23/ard-2022-223429
--- Polymyalgia rheumatica: An updated review: https://www.ccjm.org/content/87/9/549