@fortyisyoung I have a thought which might or might not apply to you. When I was about 40, I started having painful carpel tunnel in my arms. The docs I saw said nothing about other problems. But within a couple years I was having problems everywhere. joints, organs, glands, head, eyes, etc. Now, almost 50 years later I am being tested for various types of Amyloidosis Light Chain. I am pretty certain now that mine is Gelsolin, which is Systemic, primary, hereditary. It begins at conception and grows in your tissues and fluids until after you die. Most people, including doctors have never heard of it. Carpal Tunnel is one of the first signs that show up, and almost always in one's 5th generation. The testing is somewhat complicated, but not difficult. The better 1-AAA clinics and labs can do the testing for you, or if you have a local doc you trust, they can contact Mayo-AZ (Martha Grogan) or Stanford or Wherever, and ask what to do for the testing. My writeup of my history is available to anyone at https://bit.Ly/1w7j4j8, Amyloid and Old Karl. It is free, and in pdf so it can not be played with. I suggest you and your family and doc watch Martha Grogan's video on diagnosing Amyloidosis.