I have been on Lupron for 8 years and I have terrible weakness and fatigue in my thighs. Standing or walking for any length of time is very tiring. As a result, it is very difficult for me to do chores outside the house. Genital shrinking has also been very annoying, but at least my PSA level has remained low, just under 2.0 and the cancer has not metastasized to my bones or any organs although it's in my lymph system. This is surprising, since my Gleason score is 9. So, I don't complain.