I am in my 4th month on methotrexate. It was very effective at getting me to a lower prednisone dose. I was stuck at 8 mg prednisone for over a year, with multiple flare-ups when I tried to go lower. I easily dropped 1 mg/mo to 5 mg after the methotrexate was added. I hate the side effects, though, and it has caused other problems. The first three weeks on it I had severe nausea, headaches and fatigue. Now I mainly get nausea, mostly off and on for 48 hours after the weekly meth dose. I have had urinary tract infection symptoms since I got on it, but negative urinalysis. My doctor thinks I have a low level infection, my immune system is suppressed too much and he has lowered the meth dose from 12.5 to 10. I also have elevated liver enzymes, which the doctor hopes will go down on the lower dose. I've considered quitting the meth a few times.