I was titrated up to 300 xr per day for resistant major depression. I have chronic fatigue and fuzzy head. By the end of the day i usually feel better. I take the meds before bed. From experience with depression through the years i find i often feel much better at night. I guess this is normal for some types of depression. Seroquel does help with sleep. But not always. I believe it has left me with weakness in the forearms and my lower legs from the knee down. By toes also move on their own and cause cramping in the lower leg.