I haven’t taken it. My Dr. Won’t prescribe it bc he said it’s used only for pain, won’t help with the immune system. I’ve read statements that counteract that.

I don’t have IBD, but I take LDN and have an inflammatory arthritis. Before I started taking it, I did a bunch of research before deciding. There is some limited (but all research on LDN is limited; there aren’t many of the gold standard double-blind, etc. clinical trials) research specifically that has shown LDN improved IBD. If your interested, I found the study:

This was a small study ~50 people. They took 4.5 mg LDN, a very common dose. 25% of participants achieved remission, but I didn’t reread this closely enough to see if it mentions what other treatments they were doing.

While it’s true the research isn’t solid, the thing is there are very, very few side effects and very few, if any, would be considered “serious” side effects. My take on it after reviewing the research I could find and talking to my PCP who prescribed it, was that I had very little to lose, other than time and $$ because my insurance doesn’t cover it because it’s from a compounding pharmacy.

I wouldn’t swap it out for the biologic I use to treat my inflammatory arthritis—I didn’t get that much relief—but everyone’s different and that’s a decision between you and your doctor. I feel it’s worth looking into if you’re interested.

It can be difficult to persuade a doctor to prescribe it though. There are some telemedicine physicians who prescribe it, but I’ve not tried any of these. I considered it briefly because I worried we wouldn’t be able to get it for my dad (he has a different inflammatory condition), but in the end I didn’t need to do that, thankfully.

Hi, Kitty2. I was on Remicade for my UC, and it had been working well for me. Which is to say, I was pretty solidly in remission. Then for no apparent reason, I had a flare that just wouldn't quit. I had a friend with MS and found that LDN helped restore some of her hand function; she was the one who told me that it supposedly helped UC. My gastroenterologist was skeptical, but he checked the one article he could find in a bona fide medical journal, and decided it would be worth a try. The dosage for UC was 4.5 mg. I took the LDN for about 2 weeks and my flare resolved. I suppose it is possible that it might have resolved on its own, but symptoms lessened very quickly on the LDN. This all happened about 8 years ago, so there might be more current research re: dosage for UC.

Wishing you all the best...