What kind of plans are possible if you are looking ahead for many year
I am reading that Evenity is for one year; forteo/Tymlos for 2 years; Reclast for 3 years; bisphosphonates for 5 years; and Prolia for ten years of usage. I am also reading that Prolia requires a relay drug urgently if you stop taking it which may be one that you have already exhausted your life time quota. So, what are reasonable plans and sequencing if you are going to be on some sort of medication for a long period of time? For one thing, it seems like you cannot avoid Prolia as it is approved for the longest period of time of all of these.
Any thoughts?
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Well said. I am struggling with this very issue. I am 64. If I start with Evenity for a year and successfully build back my bone, can I conceivably treat myself holistically, my preferred next step? No one really talks about this approach to sequencing. All I have been reading is sequencing with more meds. I am willing to try Evenity if I know there is a non-drug solution at the end.
Keith McCormick, the chiropractor expert on osteoporosis, wrote The Whole Body Approach to Osteoporosis and more recently Great Bones (lots on meds). He himself did meds and then relied on holistic methods afterwards.
If you try Evenity and then transition to Reclast, then, according to my doc and McCormick, you may be able to take med breaks and in the meantime try natural meds. The situation can be monitored with the CTX and maybe P1NP blood tests.
My mother lost all of her teeth after thousands of dollars trying to save them. And to add insult, she had to be on a liquid diet. She was between 98 -102 when this was going on. My job was to make sure she had a supply of good chocolates ($35/lb).
My doctor is putting me on Prolia after Evenity but after reading so much about this drug, I don't want to do all of the years he's discussed. I have taken care of my teeth all of my life and don't want to lose any more than I have had to. I am sure that your mom enjoyed those chocolates!
Why is ReClast not an option for you now?
I don't know. Maybe because I already have breaks in my back.
Thanks for your educational input on estrogen. My feelings are to be bold with HRT. Women have been afraid to take it because of the flawed study with nurses 30 years ago. Most doctors are afraid to prescribe it due to the liability. Shamefully, no large studies or research has occurred to eliminate all the confusion re this very critical issue.
@dianestanley I have 7 spinal fractures and am doing Reclast after Tymlos. My docs will not prescribe Prolia unless absolutely necessary. Transition off of Prolia is fraught with risk, apparently. I have been told that if I do Reclast to lock in gains, I might be able to take a med break, with monitoring.
I can certainly understand your reluctance to go on hormones or to even consider recommending them since you have had breast cancer. There's still a lot we don't know definitively and the information out there is very confusing. What we do know is that the WHI was a flawed study and that the explanation of results was hyped and misrepresented. What was presented was the "relative risk" (I think it was somewhere around 25%) which made the risk seem quite high when in actuality, the "absolute risk" was determined to be an additional 8-9 people per 10,000, a very small increased risk. Now, any small increase in risk may be too much for some and I recognize and respect that. For those that need to arrest bone loss and are not happy with the other drug options, it's just one more thing to consider along with the risk/benefit ratio as each drug option would have.
Some other things to consider. Those on estrogen alone (only if you have no uterus) actually had a lower risk of breast cancer than those on estrogen and progesterone. There is some consideration that it may actually be the progesterone that increases risk. This needs further exploration.
The hormones used in the WHI study are different from what is generally prescribed today which are likely much safer. They used an oral estrogen, Premarin, created from pregnant mare urine. This formula contained several forms of estrogen, most of which would not be prescribed generally in menopause. Estradiol seems to be the safest in a transdermal patch at a low dose. This option bypasses the liver, unlike oral estrogen which must be processed through the liver.
The WHI study used a synthetic progestin which is now known to cause an increased risk. The safest progesterone available is micronized bioidentical progesterone.
When research studies are completed that suggest altering the course of previously held medical belief and practice, new protocols generally don't become common practice in the medical field for 15-17 years. We may be drastically behind the 8-ball here as many doctors still hold onto the decree of the WHI though there are some who are starting to shift their thinking and their recommendations.
Dr Avrum Bluming, an oncologist who has studied the research on HRT for decades has co-written a book called Estrogen Matters. He has many articles and interviews online that are very informative. Here is an interview that deals with the issue of HRT and breast cancer.
https://www.balance-menopause.com/menopause-library/explaining-what-the-evidence-shows-to-offer-choice-to-women-after-breast-cancer-with-avrum-bluming/
It's a complicated issue, no doubt. I just want to put it out there as an option to explore, research and consider depending upon one's personal situation and comfort level.
Do any of you feel, that the right answer to make a decision as to how to treat osteoporosis is so convoluted,it makes your head spin? I just want to wrap my body in shrink wrap, and wait until more studies and research studies are conducted. I will continue to do research, and hopefully insurance companies and big pharma can begin to collaborate research on post menopausal women finally!