I first had 6 rounds 1/3wks. I did not have a port and I did just fine. Some chemo regimens require a port, but mine did not. I had a second round of 12, 1/wk. the second time, a port was recommended due the the frequency. Unfortunately, my lung was punctured when the port was installed. I was in the hospital for a week and my treatment was delayed. There are two ways to install a port and I was later told that the one that was used to install mine was more likely to cause that. Ask some questions about how it will be done. It is surgery and not a simple matter.