@colorado73 - Getting regulated on Synthroid is much harder than I had ever heard about, however using the brand name eliminated some of the variables. I am working on getting the right dose for me and it is tricky. Although my TSH and T4 numbers are in the normal range the side issues were still terrible….. I have a lot of the same issues that you described. However, reducing the dose and monitoring the symptoms with the blood work has helped. I take 50 mcg a day and one day a week I take an additional dose ( 12.5 mcg…… half of a 25 mcg tablet). Having some of the negative issues improve makes me think I am on a better path and figure it will just take some time to get optimal results. One of the issues I had when seeing a previous doctor was that she just kept increasing my Synthroid and I think some of the issues I was experiencing was due to having too high of a dose. It is tricky but keep working with your doctor and go back for blood work as soon as possible when symptoms continue, so changes can be made. The headaches, insomnia, leg cramps, brain fog, depression, nausea, aches and pains will improve when the dose is right, but it’s important to use the blood level numbers AND how you are presenting to determine the best dose for you. Good luck!