I'm not sure we can determine efficacy of strontium, melatonin and micronutrients from the MOTS trial as it was a very small study with only 10 women receiving this protocol. In addition, I don't think cofounders of these participants; exercise and nutrition protocols, etc, were mentioned unless I missed that. Larger studies are definitely needed to determine the safety and efficacy of strontium. I couldn't find the Coombs study.