I have been on a PPI now ( prilosec) for probably 20 yrs. It began back when they believed there were no significant side effects. Then a study was done stating of really significant side effects.I tried desperately to get off of it--weaning down on the frequency and dose, then stopping it. I was so ill I could not eat. Lost 20#. GI doc told me to get back on it. Since then I have developed this LPR thing, and am trying to accept this as my life now. I wish I would have made it off the drug. At least now they know that when they put a patient on a PPI. It should only be for a limited time.